The geographical remit of the archeparchy includes the states of Alabama, Arkansas, Kentucky, Louisiana, Mississippi, Oklahoma, Pennsylvania, Tennessee, Texas, and West Virginia.

Byzantine Catholics in the United States were given sui iuris (self-governing) status as a Metropolia (archdiocese) by Pope Paul VI in 1969.

Archbishop Stephen Kocisko was installed as the first Metropolitan-Archbishop on June 11, 1969, at Holy Spirit Church in Oakland (Pittsburgh).

Cyril and Methodius Byzantine Catholic Seminary in the North Side section of the city, for the training of candidates for the priesthood and diaconate, cantors and those in other ministries.

Established in 1950 by Bishop Daniel Ivancho, the seminary serves all four eparchies of the Byzantine Catholic Metropolitan Church of Pittsburgh.