The archive holds over 600 fonds dating back to the 8th century which, laid out in a line, would stretch over 75 km (46 miles).
On November 4, 1966, the River Arno flooded, causing damage to over 60,000 pieces of archival material.
[2]: 193–194 The flood instigated the decision to construct a modern building for the archives further from the River Arno.
[3] It included a space for the conservation laboratory, which was founded shortly after the 1966 to recover damaged documents.
[2]: 195 Between 1987-1988 archival materials were transferred from the Uffizi to their current location, on the Viale della Giovine Italia, near the Piazza Beccaria in Florence.