It is also home to Milan's third football team, Brera, as well as being the host venue for an annual athletics meeting – the Notturna di Milano.

The team returned occasionally for relocated matches, their last being on 10 December 1958 for a Fairs Cup fixture against Lyon.

During its history it has been used for many kinds of events, including the reconstruction of naval battles; William Frederick Cody ("Buffalo Bill") twice brought his "Wild West Show" here.

Other artists who performed at the Arena include Chicago, Joe Cocker, Stewart Copeland, The Cure, Little Feat, Ben Harper, Lenny Kravitz, Lou Reed, The Manhattan Transfer, Robert Plant, Public Image Limited, Radiohead, Patti Smith, Ringo Starr, Rod Stewart, Sting and Andy Summers.

[citation needed] Inter Women announced their move to the stadium in 2023 and played their first match at the Arena Civica on 23 November 2023 against AC Milan.