Aristolochia macrophylla, Dutchman's pipe or pipevine, is a perennial vine native to the eastern United States.

This species of plant has received considerable attention in the past few decades for the discovery of a potent compound called aristolochic acid, which has been the focus of debate due its harmful side effects.

Aside from its decorative qualities, owing to its large leaves and dense growth, it is cultivated in gardens because it is a larval host for the pipevine swallowtail, Battus philenor.

The fruit then ripens, usually around September in the U.S., turns brown and splits into six fragments to disperse its small, triangular seeds.

This plant species resides largely in the Cumberland and Blue Ridge Mountains of southeastern United States.

They are native to wooded slopes, gaps, as well as ravines which are mainly in the Cumberland and Blue Ridge Mountains from West Virginia, to Kentucky, Tennessee and northern Georgia.