The route begins in southern Pope County at Galla Creek Wildlife Management Area (WMA) near the Arkansas River and runs north through Atkins.

The highway has a two-block concurrency with US 64 west in downtown Atkins beginning near the Missouri Pacific Depot, which is listed on the National Register of Historic Places.

[3] Highway 105 turns north and runs along the Atkins Commercial Historic District[4] and passes the district headquarters of Atkins Public Schools before an interchange with I-40.

ARDOT estimates the traffic level for a segment of roadway for any average day of the year in these surveys.

State Road 105 initially ran between Hector and Atkins, but was extended south near the Arkansas River on August 25, 1940.