One segment of 9.57 miles (15.40 km) runs from U.S. Route 63 (US 63) at Pansy north to US 425 south of Star City.

A second segment of 22.42 miles (36.08 km) runs from US 425 in Star City north to Huff's Island Public Use Area.

A third segment of 12.83 miles (20.65 km) runs Highway 88 at Reydell north to US 165 west of Eldridge Corner.

The route continues northeast upon entering Lincoln County, where it terminates at US 425 south of Star City.

Continuing north into White County, the route runs through Griffithville and Higginson before terminating at Highway 367 at the southern limits of Searcy.

The segment was the main automobile route in its part of Arkansas County from the time of its construction around 1916 until it was bypassed in 1955[9] by a new alignment (now US 165).