A northern route of 3.40 miles (5.47 km) runs east from Highway 23 encircling the northeastern quadrant of Booneville and ending at Highway 10.

[2] A second route of 1.02 miles (1.64 km) begins at Highway 23 and runs east to the Booneville Human Development Center.

The route runs east before turning south and terminating at Highway 10.

The average daily traffic counts from the Arkansas State Highway and Transportation Department (AHTD) for 2010 show that about 600 vehicles per day (VPD) use Highway 116.

The route winds southeast to the former Arkansas Tuberculosis Sanatorium Historic District, which was listed on the National Register of Historic Places in 2006.