The route was approximately 195 miles (314 km), and ran from US Route 67 (US 67) in Texarkana east to cross the Mississippi River near Lake Village, continuing as Mississippi Highway 10.

One section of State Road 2 original pavement, known as the Old Arkansas 2-Mayton Segment, survives north of Garland.

[3] The route served the southern tier of counties in Arkansas, connecting several cities of regional importance.

State Road 2 connected six county seats and included three toll bridges.

Several bypasses have been built since the original 1926 routing following the growth of the cities it passes through.