The route continues north to an intersection with US 70 and an interchange with Interstate 40 (I-40) in Carlisle before meeting Campground Road east of Beebe, where it terminates.

The route begins in McRae at AR 367 and runs north to an interchange with I-57/US 64/US 67/US 167.

The route begins at AR 367 near Friendly Acres Park and runs west as Missile Base Road, crossing I-57/US 64/US 67/US 167 at an interchange north of Judsonia.

The route ran about 90 miles (140 km) from the Louisiana state line to US 65 south of Pine Bluff.

In 1945, the original portion of the route was renumbered AR 81, which this section was replaced by US 425 when it was commissioned in 1989.