The route is maintained by the Arkansas State Highway and Transportation Department (AHTD).

The highway begins at US 49 in eastern Woodruff County within the Arkansas Delta between Hillemann and Bemis.

The route begins due west to an intersection with the southern terminus of Highway 145 before turning due north and running as a section line road through a rural, agricultural area.

Highway 269 crosses the Union Pacific Railroad tracks before meeting US 64.

These two routes form a concurrency west for 0.5 miles (0.80 km) until Highway 269 turns north toward Pumpkin Bend.