The highway runs west as a section line road through a rural part of the county dominated by row agriculture.

Highway 145 turns north before crossing a segment of Bayou DeView known as Reddon Lake, one of the major waterways in the region.

The highway continues north through unincorporated communities Beards and Deview before entering the small city of McCrory.

The highway runs due east as a section line road through a rural area, passing the unincorporated community of Duffy before turning north and entering Jackson County.

The highway turns due north, running as a section line road into rural Jackson County.

[17] It was extended northward to the current northern terminus at Highway 17 when a new US 64 bypass was constructed around Patterson and McCrory on January 24, 1968.

[18] The route was extended south to the current southern terminus at Highway 269 on April 25, 1973 pursuant to Act 9 of 1973 by the Arkansas General Assembly.