The route runs 5.28 miles (8.50 km) from Arkansas Highway 247 in Pottsville north across Interstate 40 to terminate at the northbound ramps.

[2] The route begins at AR 247 in Pottsville, and runs west to the Russellville Regional Airport.

The route turns north, intersecting AR 980 before forming a concurrency with US 64.

After the concurrency ends, AR 331 continues north to cross over Interstate 40 at exit 84.

Main Street is a five-lane road with a center left turn lane, and AR 331 is four-lane north of US 64.