North of these junctions, the highway crosses Interstate 40 (I-40) at a full interchange before becoming a rural route and passing through unincorporated areas.

The route runs north to the edge of the Ozark National Forest in Cleveland before turning northeast and entering Van Buren County after a few miles.

The concurrent routes pass near the Van Buren County Courthouse and Walter Patterson Filling Station, both NRHP-listed properties.

[4] US 65B terminates at the parent route, and US 65/Highway 95 run south until Highway 95 splits from US 65 near the Ozark Health Medical Center.

It is a short city street leading from the parent route to the Bosch (formerly Telex Communications) factory.