The college added intercollegiate athletics in 2010 with men's and women's basketball teams and adopted the Greyhounds mascot in recognition of a generous donation from Southland Park Gaming and Racing.

The center includes the library, multimedia rooms, office space and food service areas.

In addition, the north campus includes the Marion Berry Renewable Energy Center for Process Technology and Diesel Technology training and instruction and the Jeffrey Jacobs Hospitality and Management Center, opened in August, 2015.

The FedEx Aviation Technology Center opened in 2017 on Arkansas State University Mid-South's south campus.

The facility is equipped with a large, hands-on learning tool – a Boeing 727 jet – compliments of the global transportation company 20 miles due east.