Setzer is a native of Dayton, Ohio and graduated from the University of Dayton with a Bachelor of Science degree in business administration and from Wright State University with a Master of Education degree.
In 1982, Setzer ran for Vandalia City Council, and won her first term.
Throughout her time in the legislature, Setzer served as Chairwoman of the Education Committee, a prominent position dealing with a plethora of issues.
Term limits required Setzer to relinquish her seat in 2008, and she was replaced by Seth Morgan.
However, in 2011 Setzer ran for mayor of Vandalia, Ohio and was unopposed.