[1] Edwards led Appalachian State to one of the biggest upsets in college football history, a 34–32 victory over then fifth-ranked Michigan in 2007.

[3] He became the first quarterback in NCAA Division I history to throw for 9,000 and rush for 4,000 yards in a career, accomplishing the feat against Furman on October 31, 2009.

Edwards originally played wide receiver, but in his senior year, he moved under center.

The transition occurred late in the recruiting process, and he drew some interest from New Mexico State, Memphis, South Carolina, and Vanderbilt.

[10] Armanti Edwards led the Mountaineers to the FCS (formerly Division I-AA) National Championship in 2006 as a true freshman, beating the Minutemen of UMass 28–17.

[16] The Mountaineers began the 2008 campaign against the LSU Tigers, the first time defending FBS and FCS champions have met to open the season.

[22][23] Edwards threw a career-worst 5 interceptions in a quarterfinal loss to eventual tournament winner, Richmond, denying Appalachian State their 4th consecutive FCS championship.

[24] Before the start of the season, Edwards was involved in a lawn mowing accident, resulting in a trip to the hospital where he was treated and released.

[25] The injury sidelined him for the season opener against the East Carolina Pirates, a game which the Mountaineers would lose 29–24.

With a 27–10 victory over Elon on November 14, Edwards became the only quarterback in conference history to win four consecutive championships.

[3] Edwards's college football career ended on December 12 in a playoff semi-final game against the Montana Grizzlies.

[42][43] Edwards could see the field at a variety of positions including wide receiver, kickoff returner, and quarterback in the wildcat formation.

On December 12, Edwards featured at quarterback for one snap against the Atlanta Falcons completing a pass to fellow rookie David Gettis for no gain.

[49] On February 24, 2016, it was announced that Edwards had signed with the Saskatchewan Roughriders of the Canadian Football League.

[50] On May 27, 2017, Edwards was traded from the Roughriders to the Toronto Argonauts in exchange for offensive lineman, Peter Dyakowski.