According to researcher Kim Hekimian, the majority of Armenians arriving in the 1920s originated from the province of Adana in Cilicia of the Ottoman Empire.

Immigrants from the cities of Marash, Hadjin, and Antep together accounted for approximately 60 percents of all incoming Cilician Armenians.

The informal census taken by Ohannes Der Jachadurian in 1941 demonstrates that approximately 70 percent of the Armenians in Argentina originating from Hadjin resided in the southern neighborhoods of Buenos Aires, including Flores, Nueva Pompeya, and Villa Soldati.

Between 1947 and 1954 many Armenians from the Soviet Union, Syria and Lebanon came to Argentina as a consequence of the Second World War, and from Iran because of the Iranian Revolution in 1979.

Prior to the establishment of the church, the Armenians of Buenos Aires congregated on Sunday afternoons at a coffee shop on 25 de Mayo Street which was owned by a Jewish man from Smyrna.

[5] When more Armenian refugees arrived in Buenos Aires, the community managed to rent the Cathedral of St John the Baptist, an Anglican church which was near the coffee shop.