He was a veteran of the War of 1812, and a member of the Whig Party, who served in the Delaware General Assembly and as U.S.

She inherited the 300 acres (1.2 km2) near Leipsic that became known as Snowland or Naudain's Landing, and she and Andrew lived there and are buried there.

In 1735 he acquired farmland known as the "old Naudain homestead," which was located near Taylor's Bridge in Appoquinimink Hundred, and which, except for the period 1816–1827, remained in his descendants' hands into the 20th century.

who married Ann Elizabeth Blackiston, both dying young, Andrew S. Naudain who studied law in the office of John M. Clayton but diverted his efforts to managing the Mt.

Airy Plantation while his father served in the U.S. Senate and then went into the leather business in Philadelphia, Rebecca A. Naudain who married Hugh Alexander and lived in Chicago, and Mary H. Naudain who married William N. Hamilton M.D, who had attended school in Dublin, London and Jefferson College in Philadelphia.

from West Chester, New York, and Catherine L. Naudain who married a prominent printer of Harrisburg, Adam B. Hamilton, and Lydia Frazier Naudain who married Clayton A. Cowgill M.D., a surgeon in the Civil War, who in 1867 moved to Florida, where he bought a plantation on the St. John River at Orange Mills.

Naudain established a practice at Cantwell's Bridge, now Odessa, before age 21 and gave medical service in the War of 1812 as surgeon of the Delaware Regiment.

Naudain served as a member of the board of trustees at Newark College, later the University of Delaware, from 1833 to 1835.

An active Presbyterian layman, Naudain proposed that the university decline the proceeds of a state lottery due to the opposition of his church.

Feeling his private business suffering, Naudain resigned from the U.S. Senate and resumed the practice of medicine in Wilmington.

From 1841 until 1845 he was appointed to the position of Collector of the port and superintendent of Light Houses on the Delaware River.

He was described as "a most courteous gentleman, commanding in person, handsome in feature, and neat in attire; and evenly balanced in temperament; an humble, sincere Christian, a delightful companion, as winsome and interesting in old age as in the hey-day of youth."

In this case he was initially completing the existing term, the vacancy caused by the resignation of Louis McLane.