Arsenio Cruz Herrera (Spanish pronunciation: [ˈkɾus eˈreɾa]; December 14, 1863 – April 8, 1917) was considered the first Filipino Mayor of Manila from 1901 to 1905.

He was able to start his own law office right after graduating, a firm where Juan Sumulong and Rafael Palma were later able to work as young lawyers.

After the return of Emilio Aguinaldo in the Philippines, Cruz Herrera together with Ambrosio Rianzares Bautista and Felipe Buencamino.

Cruz Herrera rather chose to manage the official government newspaper, the El Heraldo de la Revolución.

His efforts made the revolutionary government to establish the Universidad Cientifico-Literaria de Filipinas in 1899, where he taught law.

Cruz Herrera was convinced on the peace plans of the Schurman Commission, and later joined a group that supported American autonomy in the Philippines.