The Ivano-Frankivsk Regional Art Museum was opened in 1980 in the premises of a former religious building – the Baroque Collegiate Church of the Immaculate Conception of the Virgin Mary of the 17th century (originally used as a Potocki family tomb).

at the Louvre Museum (Paris, France) November 22, 2012 – February 25, 2013 On June 21, 2013, at the 37th session of the UNESCO World Heritage Committee in Cambodia, the branch of the Prykarpattia Art Museum – the Church of the Descent of the Holy Spirit in Rohatyn was unanimously included in the World Heritage List under the nomination "Wooden churches of the Carpathian region in Poland and Ukraine" UNESCO.

The most important exhibitions are the "Religious art of Galicia in the 15th-20th centuries" (permanent collection) and baroque sculptures by Johann Georg Pinsel.

The current exhibition hall is located in the oldest architectural building of the city – the Renaissance Collegiate church of the 17th century on the square of Metropolitan Andrey Sheptytskyi.

The richest part of the museum collection is on display: icon painting of the region of the 15th-19th centuries; works of baroque plastic by Thomas Gudder, Konrad Kutchenreiter, Ioan-Georgi Pinzel, Matvii Poleiovskyi, Dionez Stanetti; paintings by the Unterberg brothers; ancient church books were published in Lviv, Pochayev, and Univ.