After reuniting, the easternmost segment of Artesia Boulevard passes through Carson, Compton, Long Beach, Bellflower, Cerritos, and La Mirada.

The road was laid out as state highway as early as 1882, when a newspaper man advised "I was requested by several parties in Artesia to state that the road recently declared a public highway from Artesia to Anaheim and Westminister has no bridge across Coyote Creek, and the two fords are through private property, the approaches to which are very steep, and after heavy rains, almost impassable and very dangerous.

[6] The intersection of Artesia and Pioneer Boulevards is the center of a Little India, a South Asian-American community and associated Indian food restaurants.

[citation needed] The southern end of the Metro J Line, Harbor Gateway Transit Center, was formerly named Artesia Transit Center, based on nearby Artesia Boulevard.

[citation needed] The intersection of Artesia Boulevard and Vermont Avenue is the southern terminus of the Dominguez Channel Bike Path.