In his initial circumscription, he included the following genera: Arthonia, Porothelium, Medusula, Ophthalmidium, Trypethelium, Astrothelium, Glyphis, Chiodecton, and Conioloma.

The family displays a diverse array of appearances, ranging from clearly visible and areolate to evanescent, hidden under bark, or even barely discernible from the substrate.

[4] The internal anatomy of the ascomata, including the pseudostromata, in this family is still an emerging area of research with potential taxonomic and systematic implications.

One noteworthy aspect is that the ascomata in Trypetheliaceae can develop either superficially or emerge from beneath the periderm, with some species even exhibiting both forms.

While septation has historically been a key differentiator, recent understandings emphasize the nature of the septa and walls as more critical taxonomic indicators.

The ascospores themselves can vary considerably, from the typical astrothelioid type to those that are multiseptate or muriform, and this variation offers important insights into the relationships within the family.

[4] Trypetheliaceae species, primarily found in tropical regions, are predominantly epiphytic, meaning these lichens mainly grow on other plants without deriving nutrients from them.

In these settings, they frequently contribute to exatensive crustose lichen communities, distinguished by their production of yellow to orange pigments.

[4] In 2020, Hongsanan and colleagues synonymized the type species of Distothelia and Novomicrothelia with Bogoriella and confirmed the placement of this genus in Trypetheliaceae.