This genus has ascomata (fruiting bodies responsible for spore production) that can be found either singularly or clustered together.

Their walls consist of intertwined hyphal threads, known as textura intricata, and have a carbonised (blackened) appearance.

[3] The hamathecium, a tissue layer inside the ascomata containing filamentous structures, is either transparent or inspersed with oil droplets.

Ascospores in Architrypethelium are typically distoseptate (having a two-part septum) and euseptate (only one wall layer is visible), predominantly brown in colour, large in size, and generally have three to five septa.

[3] Architrypethelium bears a resemblance to species in the genus Astrothelium, as well as those previously classified under Laurera, Cryptothelium, and Trypethelium.