Born in Sherbrooke, Canada East, the son of Edward Dagge Worthington (1820–1895), Worthington was educated at the Sherbrooke Academy, Bishop's College and McGill University.

He served in the North-West Rebellion in 1885, where he was awarded a medal and clasp and was mentioned in dispatches.

He took part in the South Africa Campaign in 1900–1901 and was awarded a medal and three clasps and was named in dispatches.

The election was declared void in 1905 and he was acclaimed in the resulting 1906 by-election.

He was a governor of the College of Physicians and Surgeons of the Province of Quebec and President of the District of St. Francis Medical Association.