He played 20 seasons in Major League Baseball (MLB) for the Baltimore Orioles, Seattle Mariners, Oakland Athletics, Cleveland Indians, Philadelphia Phillies, Florida Marlins, Cincinnati Reds, Texas Rangers, and St. Louis Cardinals.

Former Mariner Omar Vizquel complained that sunlight was reflecting off Rhodes' earrings; he was ordered to remove them but refused, leading to a bench-clearing brawl.

[5] On June 29, 2010, his major league record-tying streak of 33 scoreless appearances was broken by Phillies slugger Raúl Ibañez.

He was the fifth player to go to his first All-Star Game after age 40, joining Satchel Paige, Connie Marrero, Jamie Moyer and Tim Wakefield.

Given the late signing, the Rangers had to pay most of his salary, with the Cardinals responsible for only a pro-rated league minimum for the remainder of the year.

[10] On July 6, 2021, Rhodes was hired as the new pitching coach for the Cleburne Railroaders of the American Association of Independent Professional Baseball.

[11] On February 21, 2024, Rhodes was hired to serve as the pitching coach for the Lexington Legends of the Atlantic League of Professional Baseball.

[12] On October 30, 2024, Rhodes was hired to serve as the pitching coach for the Hagerstown Flying Boxcars of the Atlantic League of Professional Baseball.

Jade Rhodes also played professional softball for the Pennsylvania Rebellion (2016); Scrap Yard Dawgs (2016–17); and Cleveland Comets (2018).