He played in Major League Baseball (MLB) for the Minnesota Twins, Cincinnati Reds, Philadelphia Phillies, St. Louis Cardinals, Milwaukee Brewers, and Texas Rangers.

As of 2014, he was one of only three active non-Hispanic Native American players in MLB, with the others being Joba Chamberlain of the Cleveland Indians and Jacoby Ellsbury of the New York Yankees.

Lohse followed in the footsteps of his parents, Larry and Leslie, who were both star athletes when they attended the same high school in the 1970s.

In 1999, the Cubs traded Lohse with Jason Ryan to the Minnesota Twins for Rick Aguilera and Scott Downs.

[8] In the Cardinals’ come from behind win in Game Six of the 2011 World Series against the Texas Rangers, Lohse pinch hit in the 10th inning and delivered a key sacrifice bunt, moving the eventual tying run into scoring position.

In total, Lohse threw 7+1⁄3 innings, giving up two hits while allowing one run and striking out three.

On March 25, 2013, it was confirmed that Kyle Lohse signed a three-year, $33 million contract with the Milwaukee Brewers.

After sitting out the 2017 season, Lohse signed a minor league contract with the Kansas City Royals on March 31, 2018.

[15] Lohse's arsenal features a two-seam fastball at 90-91 mph, a biting slider in the mid 80s, a downward-fading changeup in the low 80s, and a 12-6 curveball in the low-to-mid 70s.

After signing with St. Louis and under the tutelage of Dave Duncan, Lohse started using a two-seamer, a major reason for his development.

Developing his two-seamer and refining his off-speed pitches, Lohse has become known as a very good command pitcher capable of inducing many ground-ball outs without walking many batters.

During his career in Minnesota, Lohse dedicated himself to working with Cars for Courage, an organization that serves disabled children through sports programs and activities.