Today's audiences know him as the eccentric inventor opposite Laurel and Hardy in The Big Noise (1944), and as veterinarian Doc Weaver in 39 episodes of the CBS television series Lassie.

[2] Producer Edward Finney cast Space as an urbane hoodlum in the 1941 crime drama Riot Squad, starring Richard Cromwell and released by PRC.

Under contract to MGM, Space appeared alongside Abbott and Costello in Rio Rita, and had roles in Tortilla Flat, Grand Central Murder, Andy Hardy's Double Life, and others.

Space appeared in three Republic chapter plays: Government Agents vs. Phantom Legion, Canadian Mounties vs. Atomic Invaders, and Panther Girl of the Kongo.

In 1954, Space played the bandit Black Bart, or Charles Bolles, in an episode of the syndicated Western television series Stories of the Century.

Space was cast as Ben Hudson in the 1959 episode "Hang 'Em High", on the syndicated anthology series, Death Valley Days, hosted by Stanley Andrews.