Soon afterward, the center grew to include performing arts, science exhibits, and educational programming, broadening its reach to the ten-county region of Arkansas, Ashley, Bradley, Chicot, Cleveland, Desha, Drew, Grant, Jefferson, and Lincoln counties.

After services were expanded to this region, the city council changed the name in May 1969 to Southeast Arkansas Arts & Science Center.

Although the theater was eventually restored, the galleries, offices, and collections were moved to a historic home on Martin Street.

In 1994, following a successful fundraising campaign, the current facility was built at 701 Main Street in downtown Pine Bluff.

Besides exhibiting well-known local, state, regional, national, and international artists, the center offers year-round art classes in sculpture, mixed media, and more.

The center also hosts community theater productions of both nationally famous works, such as Guys and Dolls and Barefoot in the Park, and plays by Arkansas playwrights.

The Arts & Science Center for Southeast Arkansas has developed a unique collection of photography, ranging from the documentation of the Mississippi Delta culture to the abstract.

The J.C. Covert Collection is historically significant in educating the population about life in the Delta at the turn of the 20th century, focusing on cotton fields and riverboats.