Lorenzoni began his career as a Research Fellow at IEFE, Università Commerciale Luigi Bocconi, focusing on energy economics.

From 2017 to 2020, Lorenzoni served as the Deputy Mayor of Padova, overseeing urban planning, mobility, private building initiatives, information technology systems, the digital agenda, and university relations.

Since 2020 Lorenzoni seats in Consiglio Regionale del Veneto as leader of the opposition.

With other administrators and mayors of Regione del Veneto Lorenzoni is working to a civic network named Vale.

In 2024 he became a board member of Espe s.p.a. Lorenzoni has authored more than 150 publications, with significant works including: Throughout his career, Lorenzoni has received accolades for his academic contributions and public service.