In 1521 the husband of Raden Patah's first daughter, Pati Unus attacked the Portuguese in Malacca but died in the war.

Mukmin is said to have killed Raden Kikin after Friday prayers on the banks of a river in Lasem using the kris Kyai Setan Kober which made Trenggana the third Sultan of Demak.

After Raden Kikin's death, Arya Panangsang succeeded in his father's position as Duke of Jipang.

His reign ended when he died in Panarukan, Situbondo in 1546 while trying to attack the Portuguese again to continue the struggle of Pati Unus.

With the death of Arya Panangsang, the power of the Demak Sultanate collapsed and the Kingdom of Pajang would soon be established.