The band has gone through various membership changes throughout its existence, leaving no original members, though drummer Hector "Lech" de Santiago and bassist Nick Stewart have appeared on every release to date.

As Blood Runs Black was created in 2003 in Los Angeles from an existing band known as Broken Stems by co-vocalists Louie Ruvalcaba and Enrique "Ricky" Martin, bassist Richard Reyes, and guitarists Bijon Roybal and Kyle Hasenstab.

Brian "Animal" Matute, the drummer of Broken Stems, left and was replaced by Hector "Lech" De Santiago.

However, Ruvalcaba, Martin, Reyes, Roybal and Hasenstaab all departed from the band, leaving De Santiago as the only member.

Leal would tour with As Blood Runs Black for the first half of the year before leaving to return to Upon A Burning Body.

During a tour in Anaheim, Sonik Garcia, vocalist from deathcore act Fallen Figure, joined As Blood Runs Black on the stage to perform "In Dying Days" with Maxwell.

It was unsure if Garcia was joining As Blood Runs Black as a co-vocalist, but it was revealed to just be a friendly guest appearance.

However, several months later, Maxwell departed due to a fight with one of the other members of the band, and As Blood Runs Black soon turned to Sonik Garcia to be the new vocalist.

Near the end of 2012, on a tour date in San Diego, former vocalist Chris Blair made a guest appearance for the original song "In Dying Days".

After his departure, Garcia recommended As Blood Runs Black to recruit Christopher Bartholomew, which would eventually be the sixth vocalist in the band's existence.

On August 12, 2014, drummer Hector "Lech" De Santiago released a statement which alluded to the band breaking up, saying: After YEARS of uphill battles, dealing with legalities, politics, getting robbed blind by our ex label, left for dead and getting shelved by the industry...