Asclepi is a heavily eroded lunar impact crater that lies in the rugged southern highlands of the Moon.

The outer rim has been worn down and rounded by many millions of years of subsequent impacts, so that it is now nearly level with the surrounding terrain.

The satellite crater Hommel K is a more recent impact that is attached to the southeast rim.

Nearby craters of note include Pitiscus to the north-northeast, Hommel due east, and Baco to the northwest.

By convention these features are identified on lunar maps by placing the letter on the side of the crater midpoint that is closest to Asclepi.