[1][2] She was the first child in Pakistan to be vaccinated against polio on the country's first National Immunisation Day, after her mother, then Prime Minister Bhutto, launched a major immunization drive in 1994.

During her tenure as an ambassador, Aseefa conducted campaigns to eradicate the disease, engaged with officials, and visited families affected by Polio.

[7] In June 2013, then President Asif Ali Zardari disclosed that his three children, Bilawal, Bakhtawar and Aseefa, would lead the PPP once he completed his presidential term on 9 September 2013.

[13] During the 2024 Pakistani general election, Aseefa played a pivotal role in the PPP's campaign, leading rallies in support of her brother Bilawal, who was the party's prime ministerial candidate.

[10] On 17 March 2024, she announced her entry into electoral politics by submitting nomination papers to contest the by-election for the National Assembly seat from constituency NA-207 Nawabshah-I as a candidate of the PPP.

[18] Pakistan Tehreek-e-Insaf (PTI) claimed that the nomination papers of its candidate, Ghulam Mustafa Rind, were unjustly rejected, followed by his arbitrary arrest by the police.

[22] Subsequently, Ghulam Mustafa Rind lodged a petition with the Sindh High Court (SHC) to contest Aseefa's victory, alleging that despite being a candidate in the election, his nomination papers were unfairly dismissed and that he was unlawfully arrested by the Sakrand police.