Nichols completed his legal studies, was admitted to the bar and became Clinton's partner.
Though a staunch Democrat, he was not active in politics until 1867, when he accepted the nomination for state senator and won the election by a large majority.
He was appointed New York State Comptroller in June 1870 [1] to fill the vacancy caused by the resignation of William F. Allen who had been elected to the New York Court of Appeals.
[2][3][4] In November 1870, he was elected to succeed himself for the remaining year of Allen's term, but in 1871, he was defeated for re-election by Republican Nelson K. Hopkins.
Nichols died of apoplexy at a friend's home in Clinton, and was buried at Rochester, New York.