The Twins began play as charter members of the six–team, Class Dlevel Virginia Valley League.
The Charleston Senators, Huntington, Montgomery Miners, Parkersburg Parkers and Point Pleasant-Gallipolis teams joined the Twins in beginning league play on May 5, 1910.
[6] The Charleston Senators, Huntington Blue Sox, Ironton Nailers, Montgomery Miners and Point Pleasant & Gallipolis teams joined the Twins as charter members, as the league play began on May 12, 1911.
[7][8] The 1911 Ashland-Catlettsburg Twins and the other Mountain States League teams were involved in a controversial 1911 season, which was ended early.
On July 8, 1912, playing under returning manager James Kitler, the Twins were in second place with a 26–19 record, when the franchise disbanded.