[7] In 2000, Palmer moved to New York City where she worked in summer stock, regional and children's touring theatre and independent film before being selected for the original cast of the Off-Broadway show Pieces (of Ass).

Despite her part getting cut in her first TV job, a restaurant hostess in the final season of Sex and the City, she relocated to Los Angeles in 2004 to pursue film and television work.

In 2007, when she didn't land the role played by Katie Featherston, Oren Peli offered Palmer the memorable part of Diane, who is seen in an online video having the same demonic possession as the main character.

[10] In 2010, she played Marla in the poker movie Hitting the Nuts, and appeared in on television on Criminal Minds, Desperate Housewives, State of the Union and Big Love.

[11] In 2011, Palmer was seen as a dancer in Water for Elephants and a young mom on NBC's Love Bites[12] and shot the feature film A Strange Brand of Happy with Rebecca St. James and Shirley Jones, released in 2013.