[2] Love Bites was originally[3] set to focus on "optimistic, bubbly social worker" Annie (Becki Newton) and "sarcastic career bridesmaid" Frannie (Jordana Spiro),two single women exploring modern stories of dating, marriage, love, and sex, while dealing with their other married friends.

Each story was loosely connected by common themes or romantically-challenged characters related to the pilot's three main protagonists: Annie (Becki Newton), Judd (Greg Grunberg), and Colleen (Constance Zimmer/Pamela Adlon).

Due to Newton's announced pregnancy, her character, a virgin, was reimagined, and prior to production, showrunner Cindy Chupack voluntarily reduced her role to writer, citing personal reasons.

[3][22] Pamela Adlon was originally cast as Colleen in the unaired pilot[7] and was replaced by Constance Zimmer in the subsequent aired episodes.

[5] In July 2010, Ink UMS announced that Tracy Poust and Jon Kinnally would serve as writing showrunners for the series.