[21] She co-wrote episodes such as "The Hall of Egress" and "Islands Part 4: Imaginary Resources", the latter winning a Primetime Emmy Award.

[21] The same year, she would voice characters in animation including Kamala Khan / Ms. Marvel in Lego Marvel's Avengers,[23] April O'Neil in Teenage Mutant Ninja Turtles: Mutants in Manhattan,[24] Hana in Star Ocean: Integrity and Faithlessness,[25] and Quacho Queen in World of Final Fantasy.

[30][31] She later described her voicing of Tiny Tina, Chloe, and Aloy as "three seminal step ups" that helped her "become a better actor.

[36] She would later voice characters in video games such as Afterparty,[37] Teppen,[38] Marvel Ultimate Alliance 3: The Black Order,[39] and Final Fantasy XV.

[55] That same year she voiced Danika Hart in Spider-Man: Miles Morales,[56] Viper in Valorant,[56] Jane in Ninjala,[57] Mel in The Last of Us Part II,[56] Musher in The Red Lantern,[58] and Hawkeye (Kate Bishop) in Marvel's Avengers.

[32]' Burch dated Must Come Down co-star David Fetzer until his death by accidental opioid overdose in 2012.

[65] She suffers from chronic anxiety and credits her love of video games to playing Harvest Moon as a child as it was the only thing able to calm her down.

[66][67] On July 1, 2022, Burch came out as queer and pansexual, saying that coming out felt important "for reasons I can't really explain" and that she had been dating a man for five years.