Bayram completed actors' training with Eric Morris, Los Angeles, and Anne Mertin, Vienna.

Ensuing, she appeared in a very prominent role in the black comedy "Short Cut to Hollywood",[3] shot in the US and presented at the 2009 Berlinale.

She finished the project on occasion of the commemoration of Anne Frank's 80th birthday with three performances at the Museum of Tolerance[5] in Los Angeles, Hollywood.

The Hollywood Reporter praised her performance in the film 180° stating that, "Asli Bayram in a very few scenes delivers a heartbreaking portrait of a young woman navigating between two worlds while living in neither of them.

Since 2010 Aslı Bayram is appointed honorable Ambassador for Crime Prevention by the Justice Ministry Hessen, Germany.

Since 2011 Aslı Bayram has performed the female lead role in a Turkish television serial on Star TV, Sirat.

In the same year she co-starred in the German ARD-TV film Die Wüstenärztin (The Desert Doctor), shot in Namibia, Doha and Vienna.

Asli most recently appeared in David Frankel's comedy film One Chance, alongside James Corden and Julie Walters, shot mainly in Venice and the UK.