In 2017, based on comprehensive molecular phylogenetics studies, Aspiciliella was resurrected as a separate genus within the family Megasporaceae.

Phylogenetic analyses using three genetic markers (ITS, nuLSU, and mtSSU) have confirmed Aspiciliella's position as a distinct clade within Megasporaceae.

This molecular evidence strongly supports Aspiciliella as a genus separate from Aspicilia, with which it was previously grouped based on morphological similarities.

[3] The genus Aspiciliella consists of crustose lichens, which form crust-like growths that adhere closely to the substrate.

The thallus, or body of the lichen, is typically cracked and divided into small, irregular sections (rimose-areolate), and is partially continuous across the surface it grows on.

Another distinguishing feature is the consistent presence of norstictic acid in Aspiciliella, which is only occasionally found in some Aspicilia species.