Assistant Secretary of State for International Narcotics and Law Enforcement Affairs is a position of the United States government within the Department of State that heads the Bureau of International Narcotics and Law Enforcement Affairs, which is responsible for development of policies and programs to combat international narcotics and crime.

On October 1, 1978, Congress, in the Foreign Relations Authorization Act for fiscal Year 1979, authorized the position of Assistant Secretary of State for International Narcotics Matters, to be responsible for the overall coordination of the role of the Department of State in the international aspects of narcotics problems.

The new Assistant Secretary, who headed the Bureau for International Narcotics Matters, replaced a Senior Adviser to the Secretary of State on Narcotics, who had served with a rank equivalent to an Assistant Secretary of State since 1971.

The title of this position was changed from International Narcotics Matters to International Narcotics and Law Enforcement Affairs on February 10, 1995.

The title "Assistant Secretary of State for International Narcotics Matters" was renamed "Assistant Secretary of State for International Narcotics and Law Enforcement Affairs" on February 10, 1995.