The Global AIDS Coordinator holds the rank of Ambassador-at-Large and Assistant Secretary.

Global AIDS Coordinator and Health Diplomacy (OGAC) is to lead the implementation of the U.S. President's Emergency Plan For AIDS Relief (PEPFAR), which represents the largest commitment ever by any nation for an international health initiative dedicated to a single disease.

What began as an emergency response has since developed into one of the largest international health initiatives.

PEPFAR has supported countries in the development of national health and information systems to support the fight against HIV/AIDS and other diseases, and is collaborating with countries around the world to work towards epidemic control.

PEPFAR aid has directly contributed to preventing over 20 million excess deaths in 50 countries around the world, as of June 2021.