On March 24, 1923, an arson fire destroyed the Greendale building that held both the college classrooms and the student dormitories.

[8] On June 9, 1953, a violent F4 tornado cut a path of destruction through several western and central Massachusetts communities, including the city of Worcester.

The old Assumption campus complex was sold to the state after the prep school closed and is today the home of Quinsigamond Community College.

One of the five students was also charged with intimidation and another with assault and battery with a deadly weapon, after telling campus police that he slammed the victim's head into a car door.

"[14] Assumption's 185-acre (75 ha) campus is in Worcester, Massachusetts, New England's second-largest city behind Boston, and located 43 miles (69 km) to the east.

Assumption relocated to its current location off Salisbury Street, officially opening in 1956 with the completion of La Maison Francaise.

The Chapel and adjoining Tinsley Campus Ministry Center welcome students regardless of their religion to freely practice their faith through the various Catholic and interfaith services and facilities they offer.

[17] As part of a university investment in developing a nursing program, the Richard J. and Sophia Catrambone Health Sciences Center was completed in November 2020.

[20] Assumption University teams participate as a member of the National Collegiate Athletic Association's Division II in most sports.

Longtime Assumption men's basketball head coach Andy Laska is considered a "founding father" of the conference.

Current men's sports include baseball, basketball, cross country, football, golf, ice hockey, lacrosse, soccer, tennis and track & field; women's sports include basketball, cross country, field hockey, golf, ice hockey, lacrosse, rowing, soccer, softball, swimming & diving, tennis, track & field, and volleyball.