She studied geography and political science at the Berlin University of Education from 1976 to 1980, completing her teacher training at an elementary school in Marienfelde from 1982 to 1984.

She succeeded Senator Sandra Scheeres (SPD), who held the post for ten years.

[6] Busse is considered a long-time supporter of the reintroduction of Beamter status for teachers in Berlin, which was abolished in 2004.

Upon taking office, she emphasised her belief that such a reform would be essential to solving the shortage of teachers in Berlin.

The government's coalition agreement included a commitment to reintroduce Beamter status for teachers starting from 2023 to 2024, after years of controversial debate over the issue.