The Men's 100 metres T44 event at the 2012 Summer Paralympics took place at the London Olympic Stadium on 5 and 6 September.

[1] The T44 category is for athletes who have a single below knee amputation or who can walk with moderately reduced function in one or both legs.

Prior to the competition, the existing World and Paralympic records were as follows.

rule: first 2 in each heat (Q) plus the 2 fastest other times (q) qualified.

PR = Paralympic Record.