The Men's 100 metres T53 event at the 2012 Summer Paralympics took place at the London Olympic Stadium on 3 September.

[1] The T53 category is for wheelchair athletes with normal use of arms and hands, no or limited trunk function, and no leg function.

Prior to the competition, the existing World and Paralympic records were as follows.

rule: first 3 in each heat (Q) plus the 2 fastest other times (q) qualified.

PR = Paralympic Record.