The Women's 100 metres T11 event at the 2016 Summer Paralympics took place at the Estádio Olímpico João Havelange between 8 and 9 September.

The event was won by Great Britain's Libby Clegg, guided by Chris Clarke.

Having run a world record for the classification in the semi-final, Clegg was initially disqualified for having obtained illegal assistance from her guide runner.

Upon her appeal, with her final place and world record reinstated, Clegg eased away from the Chinese pair of Zhou Guohua and Liu Cuiqing to take the gold medal.

The fourth finalist, double gold medalist and home favourite Terezinha Guilhermina was disqualified for illegal assistance.