The women's 400 metres hurdles at the 2022 Commonwealth Games, as part of the athletics programme, took place in the Alexander Stadium on 4 and 6 August 2022.

The winning margin was 0.33 seconds which as of 2024 is the narrowest winning margin for the women's 400 metres hurdles at these games.

Prior to this competition, the existing world and Games records were as follows: The schedule was as follows:[1] All times are British Summer Time (UTC+1) The first round consisted of two heats.

The three fastest competitors per heat (plus two fastest non-automatic qualifiers) advanced to the final.

[2] The medals were determined in the final.