She is writer-in-residence for 2016-2017 at Theatre Royal Stratford East in London, where her play Counting Stars was produced in 2016.
In 2009, when she was just 21, her debut play What Fatima Did premiered at the Hampstead Theatre to critical acclaim.
She followed up with Counting Stars, about two Nigerian nightclub toilet attendants working in a club in "post-Lee Rigby post-Brexit Woolwich"[5] which played at the Edinburgh Fringe 2015 and on the main stage of the Theatre Royal Stratford East in August–September 2016.
[6] As well as theatre, Sen Gupta also writes for television, beginning in 2009 when she co-wrote "Noami", an episode in the third series of Skins.
On 23 June 2016, an episode Sen Gupta co-wrote with Katie Douglas aired on BBC One's Holby City.