Atiprimod

Atiprimod (INN, codenamed SK&F106615) is a substance being studied in the treatment of certain multiple myelomas and other advanced cancers.

[citation needed] Atiprimod is an amphiphilic compound and a cation at neutral pH.

The second half of the synthesis shares features that are consonant with RS 86 The Johnson–Corey–Chaykovsky reaction on 4-Heptanone [123-19-3] (1) gives 2,2-dipropyloxirane [98560-25-9] (2).

Finally reduction of both carbonyl groups with lithium aluminium hydride completed the synthesis of Atiprimod (14).

This article incorporates public domain material from Dictionary of Cancer Terms.

Synthesis: [ 2 ] Patent: [ 6 ]
Lednicer (unofficial) synthesis [ 7 ]